microRNA 1468 (MIR1468)

MicroRNA 1468 (MIR1468) is a human-specific microRNA found in the heart, brain, and other tissues. As a microRNA, it functions primarily by binding to complementary sequences in the 3' untranslated regions of messenger RNAs, leading to their degradation or inhibition of translation[1][3]. Variant forms (miR-1468-3p and miR-1468-5p) have distinct tissue roles:\n\n- miR-1468-3p promotes aging-related cardiac fibrosis and cellular senescence, acting via enhancement of TGF-β1/p38 MAPK signaling and inhibition of dual-specificity phosphatases (DUSP1, DUSP6, DUSP8)[3].\n- miR-1468-5p functions as a tumor suppressor in glioma, inhibiting cell growth and cell cycle progression by targeting the ribonucleotide reductase large subunit M1 (RRM1)[2].\n\nExpression of MIR1468 can serve as a biomarker for disease severity or tissue aging, and antagonists ("antimiRs") of this microRNA are being studied as therapeutic agents to target cardiac fibrosis and tumor cell growth[2][3]. As a microRNA, MIR1468 is part of a molecular family involved in fine-tuning cellular phenotypes, notably in post-transcriptional regulation networks[1].

Other names

hsa-mir-1468MIRN1468mir-1468miR-1468-3pmiR-1468-5p

Synthetic antimiRs can antagonize miR-1468-3p, blocking its pro-fibrotic and senescence-inducing activities in tissue. miR-1468-5p acts as a tumor suppressor via direct inhibition of target mRNAs, such as RRM1 in glioma cells.