MicroRNA 150 (miR-150)

MicroRNA 150 (miR-150) is a highly conserved, short non-coding RNA molecule that regulates gene expression at the post-transcriptional level. It is primarily expressed in mature lymphocytes (T and B cells) and plays essential roles in cell differentiation, especially during lymphocyte development, as well as in apoptosis, proliferation, migration, and angiogenesis. MiR-150 directly binds to cellular mRNAs to induce translational repression or degradation, contributing to the regulation of hematopoietic, immune, and vascular functions. In disease, miR-150 can act as either a tumor suppressor or an oncogene, particularly in cancer, and its dysregulation is associated with several malignancies, cardiovascular pathologies, and inflammatory disorders. Due to these roles, miR-150 is considered both a biomarker and a potential therapeutic target, although its dual function in various tissues complicates clinical application.

Other names

MIR150hsa-mir-150MIRN150miRNA150mir-150

Negative regulation of gene expression via binding to target mRNAs, resulting in translational repression or mRNA degradation. Mechanism of experimental drugs would include blockade, mimicry, or inhibition of miR-150 function.