microRNA 151b (MIR151B)

microRNA 151b (MIR151B) is a small, non-coding RNA molecule found in humans and classified in the family of microRNAs that regulate gene expression post-transcriptionally, primarily by binding to complementary sequences in mRNA targets. It has been identified as one of several miRNAs downregulated in T-cell acute lymphoblastic leukemia (T-ALL) in children, suggesting a potential role in the transcriptional profiling of hematologic malignancies. There are no well-established direct disease mechanisms, therapeutic agents, or pharmacological interventions specifically targeting miR-151b. Its primary recognized role is as a biomarker in high-throughput expression assays meant for distinguishing leukemia subtypes in research settings[1][3].

Other names

hsa-mir-151bMIR151BmiR-151b

Not established for drugs; theoretical mechanism would involve base-pairing with mRNA and repression or degradation (if antagonized, would relieve this repression)