MicroRNA 153-2 (miR-153-2)

MicroRNA 153-2 (miR-153-2) is a small, non-coding RNA located in an intron of the IA-2β gene on human chromosome 7. It is evolutionarily conserved and functions to modulate gene expression post-transcriptionally by binding to mRNA targets. miR-153-2 is co-regulated with its host gene in neuroendocrine tissues and is implicated in both neuronal signaling (regulating neurotransmitter and insulin secretion) and the suppression of tumorigenesis in various cancer types[1][2][4][5]. Dysregulation of miR-153-2 has been observed in cancer progression, chemoresistance, and neurodegenerative disorders such as Alzheimer’s disease, where it targets key disease-related genes (APP, SORL1, PSEN1, KLF5, E2F3, RUNX2, TGFβ, NRF2, XIAP)[3][4]. Altered levels are linked to disease states and serve both as a mechanistic insight into pathology and a promising diagnostic/prognostic biomarker.

Other names

hsa-mir-153-2MIRN153-2mir-153-2MIR153-2

miR-153-2 is primarily a post-transcriptional regulator, binding to the 3' UTR of mRNAs to suppress translation or promote degradation. Its modulation affects pathways relevant to: - Tumor suppression: inhibits proliferation and metastasis via targeting KLF5, ZBTB2, RUNX2, E2F3, TGFβ, XIAP, and other oncogenes - Drug sensitivity: modulates chemotherapy resistance by targeting NRF2 and XIAP - Neuroprotection: inhibits amyloid precursor protein and other AD-relevant genes