MicroRNA 15b (miR-15b)

MicroRNA 15b (miR-15b) is a small non-coding RNA, approximately 22 nucleotides long, encoded by the MIR15B gene. It functions as a post-transcriptional regulator of gene expression by targeting mRNAs for degradation or translational repression, and is part of the miR-15/16 cluster. MiR-15b modulates crucial cellular processes such as cell cycle progression, apoptosis, DNA damage response, cell proliferation, and differentiation (notably in osteoblasts)[1][2][3][4]. It has complex roles in human disease, acting as either an oncogene or a tumor suppressor depending on cellular context. MiR-15b dysregulation is implicated in several cancers, cardiovascular diseases, neurodegenerative disorders, metabolic conditions, and response to radiation-induced tissue injury. Its functions are mediated through modulation of target genes involved in proliferation, survival, and DNA repair pathways, making it a potential biomarker and therapeutic target in various diseases[1][2][3][4].

Other names

hsa-miR-15bMIR15BMIRN15Bhsa-mir-15bmiR-15b-5p

Regulation of mRNA stability and translation via binding to 3' UTRs of target genes. Modulation of drug sensitivity/resistance (e.g., increasing 5-FU sensitivity in colorectal cancer). Influence on signal transduction pathways (e.g., ATM/Chk1/p53 for DNA damage response).