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MicroRNA-17 (None)
- Target
- None
- Molecular classification
- Non-coding RNA, microRNA
01
Overview
MicroRNA-17 (miR-17) is a small, non-coding RNA molecule that belongs to the microRNA class and plays a critical role in regulating gene expression at the post-transcriptional level. It is part of the miR-17/92 cluster. It functions primarily as a negative regulator of gene expression by binding to complementary sequences in the 3' untranslated regions (UTRs) of target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation. It regulates fundamental cellular processes including cell cycle progression, cell proliferation, migration, and apoptosis. It is also involved in heart, lung, and immune system development. Dysregulation of miR-17 is associated with various diseases, including cancer and fibrosis.
- Other names
- miR-17MIR17hsa-miR-17
02
Mechanism of action
Binds to 3' UTR of target mRNAs, leading to mRNA degradation or inhibition of translation
03
Biological functions
Regulation of gene expressionCell cycle progressionCell proliferationCell migrationApoptosisGene silencing
04
Disease associations
CancerB-cell lymphomaNeuroblastomaFibrosis
05
Safety considerations
Dual oncogenic/tumor-suppressive potential depending on tissue type or molecular environment
06
Biomarkers
Elevated miR-17 levels in carcinomas (prognostic marker)
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