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Target intelligence / Profile preview
microRNA 17–92 Cluster (miR-17-92)
- Target
- miR-17-92
- Molecular classification
- Non-coding RNA, MicroRNA cluster
01
Overview
The microRNA 17–92 cluster (miR-17-92) is a highly conserved polycistronic microRNA gene cluster that encodes six to seven individual mature miRNAs. It is known for its critical roles in development, cell proliferation, apoptosis, and disease processes such as cancer and neurological disorders. It functions by post-transcriptionally repressing target mRNAs.
- Other names
- miR-17-92 clustermicroRNA 17-92
02
Mechanism of action
Post-transcriptional repression of target mRNAs via binding to complementary sequences (primarily within the 3' UTRs)
03
Biological functions
Regulation of cell proliferationRegulation of apoptosisDevelopmental regulationRegulation of neurogenesisModulation of angiogenesisPost-transcriptional gene silencing
04
Disease associations
CancerNeurological disorders
05
Safety considerations
Potential for off-target effects due to broad target rangeOverexpression can promote tumorigenesis
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