MicroRNA-181a target messenger RNAs (miR-181a targets) (miR-181a targets)

MicroRNA-181a (miR-181a) target messenger RNAs (mRNAs) represent a diverse group of transcripts post-transcriptionally regulated by the miR-181a family, which plays a critical role in modulating cellular processes such as immune cell development, apoptosis, and proliferation (Indrieri et al., 2020, Int J Mol Sci). By binding to the 3' untranslated regions (UTRs) of specific mRNAs, miR-181a functions as a post-transcriptional regulator, typically leading to translational repression or mRNA degradation (Ouyang et al., 2012, J Cereb Blood Flow Metab). Key validated targets include pro-survival genes like BCL2 and MCL1, as well as signaling regulators such as SHP-2 and DUSP6, which influence T-cell receptor sensitivity and the MAPK/ERK pathway (Li et al., 2007, Nature). In oncology, the miR-181a/mRNA axis is frequently dysregulated; for instance, its downregulation can lead to the overexpression of anti-apoptotic proteins in certain leukemias, while its upregulation may drive progression in other solid tumors (Zhu et al., 2012, Blood). Therapeutic strategies involve using miR-181a mimics to restore regulation of these target mRNAs or antagomirs to block miR-181a activity, thereby modulating the expression of the entire target network to treat cancer or inflammatory diseases.

Other names

hsa-miR-181a-5p targetsmiR-181a-3p targetsMicroRNA-181a regulated transcriptsmiR-181a-5p/mRNA axis

MicroRNA-181a binds to the 3' untranslated region (UTR) of target mRNAs via seed sequence complementarity, resulting in the recruitment of the RNA-induced silencing complex (RISC), which mediates translational inhibition or mRNA decay (Ouyang et al., 2012, J Cereb Blood Flow Metab).