MicroRNA 182-5p (miR-182-5p)

MicroRNA 182-5p (miR-182-5p) is a highly conserved, small non-coding RNA that functions as a key post-transcriptional regulator of gene expression by binding to the 3' untranslated regions of target mRNAs [miRBase, 2024]. It is a member of the miR-183/96/182 cluster, which is essential for the development and maintenance of sensory organs, particularly the retina and inner ear [PubMed, 23873015]. In the context of oncology, miR-182-5p frequently acts as an oncomiR, where its upregulation promotes cell proliferation, survival, and metastasis in various malignancies, including breast, prostate, and lung cancers [NCBI, 2023]. It achieves these effects by silencing critical tumor suppressors and DNA repair genes such as BRCA1, FOXO1, and RECK [PubMed, 20404130]. Beyond cancer, miR-182-5p is implicated in the regulation of circadian rhythms and the pathogenesis of ocular diseases like glaucoma [PubMed, 28651157]. Therapeutic interventions currently under investigation involve the use of antisense oligonucleotides, such as antagomirs or locked nucleic acids (LNAs), to sequester and inhibit miR-182-5p activity in overexpressing disease states [Nature, 2017]. However, the clinical translation of these therapies faces significant hurdles, including the need for efficient delivery systems and the management of potential off-target effects resulting from the miRNA's broad regulatory network.

Other names

hsa-miR-182-5pMIR182microRNA 182miR-182

Post-transcriptional gene silencing via complementary binding to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs), leading to mRNA degradation or translational inhibition [miRBase, 2024].