MicroRNA-187-3p (miR-187-3p) (miR-187-3p)

MicroRNA-187-3p (miR-187-3p) is a small, non-coding RNA molecule that plays a critical role in the post-transcriptional regulation of gene expression (miRBase, 2024). It functions by binding to the 3' untranslated regions (UTRs) of specific target mRNAs, leading to their degradation or the inhibition of their translation (PubMed: 23045274). In the context of oncology, miR-187-3p often acts as a tumor suppressor by targeting oncogenes such as FGF9, BCL2, and SMAD7, thereby inhibiting cell proliferation and promoting apoptosis in cancers like colorectal and prostate cancer (PubMed: 27105512). However, its role can be context-dependent, as it has been observed to be upregulated and potentially oncogenic in certain malignancies like breast cancer and oral squamous cell carcinoma (PubMed: 30106424). Beyond cancer, miR-187-3p is involved in modulating inflammatory pathways, particularly through the regulation of cytokines like interleukin-10 (IL-10) and TNF-alpha (PubMed: 22430234). As a therapeutic target, miR-187-3p is being explored through the use of miRNA mimics to restore its function in downregulated states or antagomirs to inhibit its activity when overexpressed in disease states.

Other names

hsa-miR-187-3pMIR187MicroRNA 187miR-187

Binds to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs) to induce translational repression or mRNA degradation, thereby silencing specific gene expression.