MicroRNA 1908 (miR-1908)

MicroRNA 1908 (miR-1908) is a highly conserved, non-coding RNA that regulates gene expression post-transcriptionally by binding to the 3’ untranslated region of target mRNAs, thereby inhibiting their translation or promoting their degradation[1][2]. Its expression is dysregulated in multiple diseases and has dual roles in cancer—acting as an oncogene in some contexts (e.g., breast cancer, cervical cancer, glioma, osteosarcoma) and as a tumor suppressor in others (e.g., non-small cell lung cancer, ovarian cancer, chordoma)[2][3]. miR-1908 impacts key processes such as cell proliferation, differentiation, apoptosis, invasion, and metastasis, and is regulated by numerous factors including lncRNAs, adipokines, transcription factors, metabolites, and drugs[1]. Given its regulatory breadth and disease associations, miR-1908 is of considerable interest both as a potential therapeutic target and as a biomarker in cancer and complex diseases[1][2][3][5].

Other names

hsa-miR-1908MIR1908MIRN1908hsa-mir-1908mir-1908miR-1908-3pmiR-1908-5p

Drugs or molecules that alter miR-1908 levels act through transcriptional or post-transcriptional regulation, resulting in altered suppression or activation of target genes (e.g., via binding to 3' UTR of mRNAs)