microRNA 1915 (miR-1915)

MicroRNA 1915 (miR-1915) is a small, single-stranded, non-coding RNA of approximately 21–23 nucleotides that functions as a post-transcriptional regulator of gene expression by binding mRNA targets and promoting their degradation or translational repression[2][3][4]. In cancer biology, miR-1915-3p acts predominantly as a tumor suppressor by targeting oncogenes such as SET, BCL2, and others, thereby inhibiting cell migration, invasion, and epithelial-mesenchymal transition (EMT)[1]. Its downregulation has been linked to increased cancer aggressiveness, poorer survival, and multidrug resistance, especially in non-small-cell lung cancer and other malignancies[1]. miR-1915-3p is regulated epigenetically through mechanisms like METTL3/YTHDF2/KLF4 axis affecting its expression, and its tissue-specific expression and stability support potential biomarker utility in oncology[1][3]. There are currently no approved drugs directly targeting miR-1915, but manipulation of its levels is of growing interest for anti-metastatic cancer therapy[1][4].

Other names

hsa-mir-1915miR-1915-3pMIR1915MIRN1915

miR-1915-3p binds to complementary sequences in 3'UTR of mRNA targets, suppressing translation or degrading mRNA[1][2]. Suppresses oncogenic targets such as SET, BCL2, RAGE, PROM1, PAX2, and NFIX, thereby inhibiting tumor growth, invasion, and metastasis[1].