MicroRNA 193a-3p (miR-193a-3p)

MicroRNA 193a-3p is a highly conserved, small non-coding RNA that is processed from the MIR193A gene located on human chromosome 17q11.2[1]. It functions mainly as a post-transcriptional regulator by binding to target mRNAs and suppressing their translation or promoting degradation[2][6]. MiR-193a-3p is well-established as a tumor suppressor in various human cancers, exerting its role by inducing cell cycle arrest, apoptosis, and inhibiting cancer cell migration, invasion, and metastasis[2][3][4][6][9]. Its dysregulation contributes to tumorigenesis, progression, and chemoresistance[1][9]. Additionally, miR-193a-3p influences the tumor microenvironment, modulating immune responses and potentially priming long-term antitumor immunity via dendritic cell activation and T cell priming[3]. Measurement of circulating or tissue levels serves as a diagnostic and prognostic biomarker in cancer and certain neurological disorders[2][7]. Preclinical research explores synthetic mimics (such as INT-1B3) for therapeutic restoration of miR-193a-3p function, but clinical translation faces challenges of delivery, efficacy, and safety[3][8].

Other names

miR-193a-3pMIR193A-3p

Mimics/inhibitors: supplement or suppress miR-193a-3p activity, altering post-transcriptional regulation of oncogenes and tumor suppressor genes\nInduction of immunogenic cell death, priming dendritic cells, activation of cytotoxic T cells