MicroRNA 196a-1 (MIR196A1)

MicroRNA 196a-1 (MIR196A1) is a member of the microRNA (miRNA) family, a class of short (20–24 nucleotide) non-coding RNAs involved in the post-transcriptional regulation of gene expression by promoting the degradation or inhibiting the translation of target mRNAs[2][1][8]. MIR196A1 is transcribed from the HOXB gene cluster locus in humans, and its mature sequence is identical to its paralog miR-196a-2 but differs from miR-196b by one nucleotide[5]. MIR196A1 regulates key developmental and cellular processes, including cell proliferation, apoptosis, migration, and invasion, by targeting mRNAs such as HOXB8, HMGA2, annexin A1, and BRAM1[1][3][6][7]. Dysregulation of miR-196a-1 expression has been observed in multiple malignancies (notably breast, renal, colorectal, and gastric cancers), where it acts as an oncomiR, promotes tumor progression and metastasis, and serves as a prognostic biomarker[4][5][6]. While miR-196a-1 itself is not a traditional receptor or enzyme, it is considered a potential therapeutic target due to its central regulatory role in tumorigenesis and its biomarker utility in disease stratification and monitoring. No clinically approved drugs target miR-196a-1 directly, but anti-miR oligonucleotide strategies are being explored in preclinical and investigational contexts[3][6].

Other names

hsa-mir-196-1hsa-mir-196a-1MIRN196-1MIRN196A1mir-196a-1microRNA 196-1microRNA 196amicroRNA miR-196miR-196a-1

Antisense inhibition of mature microRNA (for antagomir, anti-miR, or oligonucleotide drugs targeting miR-196a-1). Restoration of tumor suppressor targets by blocking miR-196a-1.