microRNA 1972-2 (miR-1972-2)

microRNA 1972-2 is a non-coding RNA gene that encodes a ~22-nucleotide microRNA involved in post-transcriptional regulation of gene expression. Like other microRNAs, miR-1972-2 is processed from a primary transcript, incorporated into the RNA-induced silencing complex (RISC), and regulates gene expression typically by binding imperfectly to target mRNAs, resulting in translational repression or degradation. Research in cell lines suggests miR-1972 may regulate genes involved in proliferation, metastasis, and angiogenesis—especially impacting breast cancer cell migration and growth as well as expression of angiogenesis markers and von Willebrand factor (VWF). No drugs have been documented to directly interact with MIR1972-2; however, experimental use of microRNA mimics or inhibitors is ongoing in research contexts.

Other names

hsa-miR-1972-2MIR1972-2microRNA 1972-2

Gene silencing via RNA-induced silencing complex (RISC); Translational inhibition or target mRNA destabilization through imperfect base-pairing with mRNA's 3' UTR.