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Target intelligence / Profile preview
MicroRNA 199a-3p (miR-199a-3p)
- Target
- miR-199a-3p
- Molecular classification
- Other (microRNA)
01
Overview
MicroRNA-199a-3p is a small non-coding RNA that functions as a tumor suppressor by regulating the expression of genes involved in cell proliferation, migration, and apoptosis. It is downregulated in various cancers, including osteosarcoma, hepatocellular carcinoma, and glioma. miR-199a-3p targets several oncogenes and anti-apoptotic genes, including Met, mTOR, Stat3, and Bcl-XL, thus inhibiting tumor growth and progression. Its potential as a therapeutic target or biomarker is being explored for cancer treatment.
02
Mechanism of action
Acts as a tumor suppressor by downregulating oncogenes and anti-apoptotic genes, such as Met, mTOR, Stat3, MCL-1, and Bcl-XL, which are involved in cell proliferation, survival, and migration.
03
Biological functions
Cell proliferationCell migrationApoptosisCell cycle regulationSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Potential therapeutic challenges include ensuring effective delivery and sustained expression of miR-199a-3p in cancer cells.
06
Biomarkers
Potential biomarker for distinguishing osteosarcoma tissues from normal tissues
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