MicroRNA 199b-3p (miR-199b-3p)

MicroRNA 199b-3p (miR-199b-3p) is a small non-coding RNA molecule that serves as a critical post-transcriptional regulator of gene expression. It functions by binding to the 3' untranslated regions (UTRs) of target messenger RNAs (mRNAs), leading to their degradation or translational inhibition via the RNA-induced silencing complex (RISC). miR-199b-3p is involved in several essential biological processes, including the regulation of the cell cycle, apoptosis, and the epithelial-mesenchymal transition (EMT) (Source: PubMed, PMID: 27167198). In many clinical contexts, miR-199b-3p acts as a tumor suppressor, and its downregulation is frequently observed in malignancies such as hepatocellular carcinoma, breast cancer, and colorectal cancer (Source: NIH, PMC4102794). By targeting oncogenic pathways like AKT/mTOR and p21-activated kinase 4 (PAK4), it helps maintain cellular homeostasis and prevents uncontrolled proliferation (Source: PubMed, PMID: 25169962). While no therapies targeting miR-199b-3p are currently FDA-approved, it is a significant focus of research for oligonucleotide-based therapeutics. Potential treatments include miRNA mimics designed to restore its expression in cancer and antagomirs aimed at modulating its activity in other pathological states such as cardiac hypertrophy (Source: Nature Reviews Drug Discovery).

Other names

hsa-miR-199b-3pMIR199BmiR-199b

Binds to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs) to inhibit translation or promote mRNA cleavage via the RNA-induced silencing complex (RISC).