microRNA-200b-3p (miR-200b-3p)

microRNA‑200b‑3p is a small non-coding RNA molecule belonging to the miR‑200 family. It functions primarily as a tumor suppressor by regulating gene expression at the post-transcriptional level. In cancers such as triple-negative breast cancer, its expression is often significantly reduced. Overexpression of miR‑200b‑3p inhibits epithelial-to-mesenchymal transition (EMT), cell migration, proliferation, and invasion by targeting key signaling pathways including RHO signaling and LIMK1/CFL1[1][2]. Its loss is associated with increased metastatic potential in several cancers. The canonical targets include transcription factors like ZEB1/2 that repress epithelial markers such as E-cadherin[1]. miR‑200b‑3p has also been implicated in other biological processes beyond oncology, including diabetic retinopathy[3]. As a regulatory RNA rather than a protein receptor or enzyme, it does not have direct drug interactions but may be modulated by nucleic acid-based therapeutics designed to mimic or inhibit its function.

Other names

miR-200bMIR200Bhsa-miR-200b-3pmicroRNA 200b-3p

Post-transcriptional repression of target mRNAs involved in EMT and metastasis (e.g., ZEB1/2, LIMK1/CFL1 pathway)[1][2]