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Target intelligence / Profile preview
MicroRNA-210 (miR-210)
- Target
- miR-210
- Molecular classification
- microRNA, Non-coding RNA
01
Overview
MicroRNA-210 (miR-210) is a highly conserved, small non-coding RNA molecule that regulates gene expression post-transcriptionally. It is strongly induced by hypoxia and plays a central role in cellular responses to low oxygen levels. miR-210 influences a variety of biological processes including mitochondrial metabolism, angiogenesis, cell proliferation, and apoptosis. Dysregulation of miR-210 is implicated in diseases such as cancer and cardiovascular diseases.
- Other names
- mir-210hsa-miR-210
02
Mechanism of action
miRNAs guide the RNA-induced silencing complex (RISC) to complementary sequences on target mRNAs—primarily within their 3′ untranslated regions (UTRs)—to inhibit translation or promote degradation.
03
Biological functions
Hypoxia response regulationMetabolism controlAngiogenesisCell proliferationApoptosisDNA damage responseCell survival
04
Disease associations
CancerCardiovascular diseaseMyocardial infarctionTissue ischemiaInflammation
05
Safety considerations
Can function as either an oncogene or tumor suppressor depending on cancer type/context
06
Biomarkers
Coronary artery disease risk/prognosisMyocardial infarction
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