MicroRNA-214 (miR-214)

MicroRNA-214 (miR-214) is a small, non-coding RNA molecule that plays a crucial role in post-transcriptional gene regulation by binding to the 3'-untranslated regions of target messenger RNAs, thereby inhibiting protein production or promoting mRNA degradation. It is involved in a wide array of biological processes, including cell proliferation, differentiation, apoptosis, angiogenesis, and immune responses. MiR-214 exhibits pleiotropic and often contrasting roles, acting as both an oncogene and a tumor suppressor in various cancers such as gastric, lung, ovarian, and breast cancers, depending on the specific cellular context and its downstream targets. Beyond cancer, miR-214 is implicated in cardiovascular diseases, bone formation, and neurodegenerative conditions like Amyotrophic Lateral Sclerosis (ALS).

Other names

miR-214MIR214hsa-miR-214MIRN214hsa-miR-214-3phsa-miR-214-5pmiRNA214

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level by binding to the 3' untranslated region (3'-UTR) of target mRNAs, leading to inhibition of protein production or mRNA degradation. Specific targets of miR-214 include PTEN, ATF4, Sp7, MAP2K3, MAPK8, UBC9, RFWD2, UCP2, RNF8, ARL2, NCKAP1, NCX1, BIM, CaMKIIδ, CypD, EZH2, Xotx2, Xvsx, and ESR1.