microRNA-23b-5p (miR-23b-5p)

microRNA-23b-5p (miR-23b-5p) is a small, non-coding RNA that regulates gene expression post-transcriptionally, influencing mRNA stability and translation[2][4]. miR-23b-5p plays complex roles in biological processes including cell proliferation, differentiation, apoptosis, immune function, and adipocyte metabolism. It has been shown to act as either a tumor suppressor or oncogene depending on cellular context[4]. In brown adipose tissue, miR-23b-5p functions as a negative regulator of thermogenic gene programs, impairing mitochondrial content and oxidative capacity when overexpressed[1]. Disease associations include various cancers, autoimmune diseases, and cardiovascular pathology, and it may serve as a non-invasive biomarker (e.g., in IPMN via saliva testing)[2][4]. Its broad impact on gene networks makes it a candidate therapeutic target and biomarker, but also presents challenges for therapeutic specificity and safety[4][1].

Other names

miR-23b-5phsa-miR-23b-5pmiR-23bmiR-23b-5p mature miRNA

Post-transcriptional inhibition of target mRNAs via binding to 3' UTRs