microRNA-23c (miR-23c)

microRNA-23c (miR-23c) is a member of the microRNA family, a class of small non-coding RNAs (typically 19–25 nucleotides) that regulate gene expression primarily by binding to complementary sequences in the 3′ untranslated regions (3′-UTRs) of target messenger RNAs (mRNAs), resulting in translational repression or mRNA degradation[3]. miR-23c shares its seed sequence with miR-23a-3p and miR-23b-3p, forming part of the same microRNA family[1]. Recent studies have identified significant downregulation of miR-23c expression during prostate cancer progression, particularly in bone metastases compared to localized prostate cancer and benign tissue. Forced overexpression of miR-23c in prostate cancer cell lines reduces cell proliferation in vitro, suggesting tumor suppressor-like properties, though in vivo evidence for tumor suppression is limited[1]. The expression and functional effects of miR-23c in other tissues and disease contexts remain less characterized.

Other names

miR-23cMIR23Chsa-miR-23chsa-mir-23cmir-23c

Not established for drugs; microRNA-23c acts through post-transcriptional repression of mRNA targets