MicroRNA-27 (miR-27)

MicroRNA-27 is a highly conserved, small, non-coding RNA that post-transcriptionally regulates gene expression by binding to partially complementary sequences in the 3′ untranslated regions of target mRNAs, inducing translational repression or mRNA degradation. The miR-27 family consists of miR-27a and miR-27b, which are encoded by separate genomic loci as part of the Mir-23-27-24 clusters. miR-27 plays crucial roles in cellular proliferation, apoptosis, metabolism, adipogenesis, angiogenesis, and developmental processes. Dysregulated miR-27 expression is associated with a broad spectrum of disease states including cancer, fibrosis, cardiovascular, and metabolic diseases. Its activity in multiple essential pathways makes it a promising, but complex, therapeutic and biomarker candidate.

Other names

miR-27miR-27amiR-27bmiRNA-27miRNA-27amiRNA-27b(encoded as part of Mir-23-27-24 clusters [specifically Mir-23a-27a-24-2 and Mir-23b-27b-24-1])

Antisense inhibition (anti-miR or LNA-mediated): Antisense oligonucleotides bind miR-27, preventing its interaction with target mRNAs. miRNA mimics: Synthetic miR-27 molecules supplement endogenous function, increasing post-transcriptional regulation of target genes. Translational repression: Modulators of miR-27 affect the translation (and sometimes subsequent stability) of specific target mRNAs such as HMGCR, EGFR, PHB, and PPARγ.