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Target intelligence / Profile preview
microRNA-27a (miR-27a)
- Target
- miR-27a
- Molecular classification
- MicroRNA, Non-coding RNA
01
Overview
microRNA-27a (miR-27a) is a small non-coding RNA that regulates gene expression post-transcriptionally. It plays critical roles in various physiological and pathological processes, including cancer, metabolism, immune response, and cell differentiation. It functions by binding to the 3' UTR of target mRNAs, leading to translational repression or mRNA degradation. miR-27a can act as either an oncogene or a tumor suppressor depending on the cellular context.
- Other names
- hsa-miR-27aMIR27A
02
Mechanism of action
Binds to 3' UTR of target mRNAs to repress translation or induce mRNA degradation.
03
Biological functions
Gene expression regulationCell proliferationApoptosisCell differentiationMetabolic regulationImmune responseEpithelial-mesenchymal transition (EMT)
04
Disease associations
Cancer (various types)ObesityType 2 diabetes mellitusInflammatory disorders
05
Safety considerations
Context-dependent effects (oncogene vs. tumor suppressor)Potential for off-target effects
06
Biomarkers
Diagnosis/prognosis in various cancers
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