MicroRNA 2861 (miR-2861)

MicroRNA 2861 (miR-2861) is a highly conserved microRNA found in humans and other mammals, predominantly expressed in osteoblasts and bone tissue. It promotes osteoblast differentiation and bone formation by targeting and repressing histone deacetylase 5 (HDAC5), thereby stabilizing Runx2 protein, a critical transcription factor for bone development[1][3]. A mutation in pre-miR-2861 can lead to primary osteoporosis by reducing miR-2861 expression. Beyond bone biology, miR-2861 regulates cell proliferation and apoptosis in human retinal vascular endothelial cells by targeting NDUFB7, indicating a role in diabetic retinopathy pathophysiology[2]. There are currently no drugs specifically approved that target miR-2861, but its activity may be modulated in experimental settings with antagomirs or genetic tools. miR-2861 is under investigation for its biomarker potential in skeletal disorders and diabetic eye disease. Therapeutic modulation carries theoretical safety risks related to bone and vascular health. If additional context is needed for tissue specificity or gene sequence, the miRBase registry and PMC articles provide further molecular details[1][2][3].

Other names

MIR2861hsa-mir-2861BMND15MIRN2861

Gene silencing via sequence-specific binding to target mRNAs (HDAC5, NDUFB7), resulting in translational repression and altered protein expression