MicroRNA 302b (miR-302b)

MicroRNA 302b (miR-302b) is a short non-coding RNA molecule involved in the post-transcriptional regulation of gene expression[2][3]. It is a member of the miR-302/367 cluster, highly expressed in embryonic stem cells and linked to processes that maintain pluripotency and promote somatic cell reprogramming[1][4]. miR-302b acts by binding messenger RNAs (mRNAs), thereby inhibiting translation or destabilizing the target mRNAs. Biologically, it has roles in suppressing cell proliferation, regulating immune and inflammatory responses (notably as a negative regulator of NF-κB signaling during bacterial infections), and modulating oxidative stress. Disease associations include influence as a tumor suppressor in several cancers and as a biomarker for cancer prognosis and drug sensitivity, especially increasing sensitivity to chemotherapeutic agents like 5-FU in liver cancer cells. Its broad regulatory activity is both a source of therapeutic promise and of safety concerns, particularly regarding unintended effects on pluripotency and stem cell biology[1][2][4][5][6][7].

Other names

hsa-mir-302bMIRN302BMIR302Bmir-302b

Post-transcriptional inhibition (translational repression or mRNA destabilization) of target genes such as EGFR, Mcl-1, DPYD, IRAK4