MicroRNA 302c (miR-302c)

MicroRNA 302c (miR-302c) is a small, non-coding RNA molecule that belongs to the conserved miR-302 family, which is abundantly expressed in early embryonic stem cells and is critical for maintaining pluripotency, regulating differentiation, and repressing premature neural and somatic development[1][5]. It functions by post-transcriptionally silencing key developmental genes and transcription factors, thus modulating cellular states related to renewal and differentiation in embryogenesis and cancer. In cancer, miR-302c has been identified as a regulator of chemosensitivity, notably by targeting P-glycoprotein and affecting resistance to drugs such as temozolomide, 5-fluorouracil, adriamycin, and cisplatin[2]. Deregulation of miR-302c is associated with chemoresistance and tumor progression, and it is being explored as a therapeutic target and biomarker in oncology and regenerative medicine. Additionally, miR-302c plays an essential role in neural tube closure and embryonic viability, highlighting potential therapeutic challenges related to its systemic modulation[5].

Other names

hsa-miR-302cMIR302CMIRN302Cmir-302c

Post-transcriptional gene silencing via binding to 3' UTRs of target mRNAs[1][2]; Suppression of P-glycoprotein (P-gp/ABCB1), leading to increased chemosensitivity[2]; Regulation of transcription factors and developmental signals[1]; Regulation of cell fate by attenuating expression of differentiation genes[1]; Targeting Fgf15 and regulating neural differentiation[5]