microRNA 3064 (miR-3064)

microRNA 3064 (miR-3064) is a small, non-coding RNA molecule categorized as a microRNA. It regulates gene expression post-transcriptionally by binding to complementary sequences in the 3'-untranslated region (3'-UTR) of target mRNAs, leading to their degradation or translational repression[2][3]. In ovarian cancer, miR-3064 is down-regulated and functions as a tumor suppressor by directly targeting the 3'-UTR of human telomerase reverse transcriptase (hTERT) mRNA, leading to reduced hTERT levels and inhibition of cancer cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Low expression of miR-3064 in ovarian cancer specimens correlates with advanced clinical stage, higher tumor grade, increased metastasis, and poorer patient survival[2][3]. In hepatocellular carcinoma and epicardial adipose tissue, miR-3064-5p influences disease by modulating angiogenesis and adipogenic differentiation, targeting genes such as FOXA1 and Nnat[1]. Currently, miR-3064 is not classified as a conventional therapeutic target (such as a receptor or enzyme) but is actively studied as a regulatory RNA and potential biomarker in cancer and cardiovascular disease[2][3][1].

Other names

hsa-miR-3064MIR3064hsa-mir-3064microRNA-3064-5p