MicroRNA 30a (miR-30a)

MicroRNA 30a (miR-30a) is a highly conserved, small non-coding RNA (18–25 nucleotides) belonging to the miR-30 family, encoded by the MIR30A gene on chromosome 6q.13[1][6]. It acts as a post-transcriptional regulator of gene expression by binding to complementary sequences in the 3′ untranslated regions of target mRNAs, leading to translational repression or mRNA degradation. miR-30a participates in key biological processes including cell cycle regulation, apoptosis, inhibition of cell migration and invasion, autophagy control, and EMT. Functionally, miR-30a is generally considered a tumor suppressor in a range of cancers by downregulating target genes such as TM4SF1, CD73, IGF1R, and BECLIN-1, thereby inhibiting tumor progression, metastasis, and drug resistance[1][2][4][5]. It also plays a role in metabolic homeostasis and inflammation, with reduced expression associated with poor outcomes in metabolic and autoimmune diseases. Because of its dysregulation in disease, miR-30a is under investigation as both a biomarker and a therapeutic target[1][3][6].

Other names

hsa-mir-30aMIR30AMIRN30Amir-30a

Modulation of miR-30a expression (e.g., overexpression or mimic administration) suppresses oncogene or fibrosis-related target genes at the mRNA level, primarily through translational repression or mRNA destabilization