MicroRNA-30b (miR-30b)

MicroRNA-30b (miR-30b) is a highly conserved, small noncoding RNA encoded on human chromosome 8q24.22 and is a member of the miR-30 family, which post-transcriptionally regulates gene expression by binding target messenger RNAs. It plays important roles in controlling cell apoptosis, proliferation, differentiation, epithelial–mesenchymal transition, immune cell polarization, and angiogenesis by directly targeting numerous protein-coding genes, including key oncogenes, tumor suppressors, and signaling mediators such as CCNE2 (cell cycle control), EGFR/AKT/Derlin-1, SIX1/snail (EMT), and JDP2 (transcriptional regulation of TGFβ2)[1][3][4]. miR-30b generally acts as a tumor suppressor in most cancers by inhibiting malignant behaviors, reducing drug resistance, and supporting apoptosis, but its roles are context dependent. Its expression and molecular targets also participate in immune pathway regulation (e.g., macrophage differentiation via the MALAT1/miR-30b axis)[3], and in vascular biology by modulating endothelial morphogenesis[4]. Because of these broad regulatory features, miR-30b is studied as both a biomarker and a potential therapeutic target, though further clinical validation and safety data are needed for translational applications[1].

Other names

hsa-mir-30bMIRN30BMIR30Bmir-30bhsa-miR-30b

Modulation of drug sensitivity/resistance by targeting protein-coding genes involved in cell cycle (e.g., CCNE2)[1] - Regulation of signal transduction pathways (PI3K/AKT, EMT regulators, TGFβ2, etc.)[1][4] - Regulation of downstream targets that affect apoptosis and proliferation[1]