MicroRNA 30c-2 (miR-30c-2)

MicroRNA 30c-2 (miR-30c-2) is an endogenous small noncoding RNA (microRNA) encoded by the MIR30C2 gene, located on human chromosome 6q13[1][4]. It plays a key role in the post-transcriptional regulation of gene expression by binding to the 3' untranslated regions (3'UTRs) of target mRNAs, resulting in mRNA degradation or translational inhibition[2][4]. miR-30c-2 belongs to the miR-30 family, which is involved in various cellular processes, including cell proliferation, differentiation, apoptosis, and tumor progression[4][1]. The mature miR-30c-2 is incorporated predominantly into the RNA-induced silencing complex (RISC), where it guides the complex to specific target mRNAs[2]. In cancer, miR-30c-2 functions as a tumor suppressor: its expression is induced by mitogenic signals such as lysophosphatidic acid (LPA), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF)[1]. Increased miR-30c-2 levels have been shown to reduce cancer cell proliferation and viability, in part by downregulating oncogenic targets like BCL9 and CREM, thus impacting cell cycle progression and possibly chemoresistance in breast and ovarian cancers[1][4][3]. There are currently no approved drugs that directly target miR-30c-2, but it is explored as a biomarker for patient selection and prognosis in certain cancers and as a potential future therapeutic target or modulator in oncology[4][3].

Other names

MIR30C2hsa-mir-30c-2MIRN30C2mir-30c-2miR-30c