MicroRNA 30d (miR-30d)

MicroRNA 30d (miR-30d) is a small, highly conserved, non-coding RNA that regulates the expression of numerous genes post-transcriptionally by binding target mRNAs[1][4][5]. miR-30d is part of the larger miR-30 family and is located at chromosome 8q24.22[4]. Its aberrant expression has been observed in a wide range of cancers, functioning either as a tumor suppressor or oncogene depending on cellular context[1][4]. Key targets of miR-30d include GNA13 (in colorectal cancer)[1], EZH2 (in esophageal cancer)[4], and multiple autophagy pathway genes (BECN1, BNIP3L, ATG12, ATG5, ATG2)[3]. By regulating these targets, miR-30d is involved in critical biological processes including cell proliferation, migration, invasion, differentiation, apoptosis, and autophagy[1][3][4][6]. Altered miR-30d expression is associated with tumor progression, metastasis, and can serve as a diagnostic or prognostic biomarker across multiple cancer types[1][2][4][6]. Its molecular actions and disease associations make it a promising therapeutic target and biomarker in oncology research, though clinical applications remain experimental due to general challenges in miRNA-based therapeutics[3].

Other names

miR-30dMIR30Dhsa-mir-30dMIRN30Dmir-30d

Drugs or molecular agents modulating miR-30d could act via inhibition (antagomirs), mimicking (miRNA mimics), or altering upstream regulators such as lncRNAs.