MicroRNA 3135a (MIR3135A)

MicroRNA 3135a is a short (~20-24 nucleotide) non-coding RNA classified as a human microRNA (miRNA)[1][3]. MicroRNAs are transcribed primarily by RNA polymerase II as part of longer primary transcripts (pri-miRNAs), which are cleaved in the nucleus by Drosha to generate precursor miRNAs. These are exported to the cytoplasm, further processed by Dicer, and the mature miRNA is then loaded onto the RISC complex, which targets specific mRNAs by imperfect base pairing, resulting in gene silencing via translational inhibition or mRNA destabilization[1][6][7]. While thousands of microRNAs are cataloged in the human genome, current literature on MIR3135A identifies an association with autism spectrum disorder, but detailed regulatory targets, interacting drugs, or mechanistic therapeutic roles are largely unknown.

Other names

MIR3135hsa-mir-3135hsa-mir-3135amicroRNA 3135microRNA 3135aMIR3135A

Not directly targeted by drugs; general microRNA mechanism involves incorporation into the RNA-induced silencing complex (RISC), which binds to complementary sequences on target mRNAs to inhibit their translation or promote their degradation