MicroRNA 3142 (miR-3142)

MicroRNA 3142 (miR-3142; hsa-mir-3142) is a short, non-coding RNA molecule involved in post-transcriptional regulation of gene expression, primarily by mediating mRNA destabilization or translational inhibition. miR-3142 has been implicated in oncogenesis and chemoresistance, particularly via downregulation of the tumor suppressor PTEN, resulting in activation of the PI3K/Akt signaling pathway. This microRNA has been proposed as a non-invasive serum biomarker for the detection and prognosis of cancers such as cervical cancer and plays roles in promoting cell proliferation, suppressing apoptosis, and mediating chemotherapy resistance in leukemia cell models[1][2][3].

Other names

hsa-mir-3142MIR3142HGNC:38297NCBI Gene:100422938Ensembl:ENSG00000265237

Modulation of gene expression (mainly inhibition of PTEN leading to activation of PI3K/Akt pathway); indirect modulation of apoptosis and cell proliferation-related pathways