Target intelligence / Profile preview

microRNA 3145 (miR-3145)

Target: miR-3145
Molecular classification: microRNA, Non-coding RNA, RNA gene regulator

Overview

microRNA 3145 is a human-origin microRNA encoded within the intronic region of the NHSL1 gene. It acts as an antiviral regulator with the ability to suppress replication of viruses such as hepatitis B virus (HBV) by binding the highly conserved pol region of the HBV genome; expression is upregulated in response to HBV infection and is associated with favorable prognosis in hepatocellular carcinoma. It also inhibits replication of multiple influenza A virus subtypes by silencing the viral PB1 polymerase gene. Its biological role makes it a potential candidate for novel antiviral therapies, though optimized delivery and safety remain under investigation

Other names: MIR3145hsa-miR-3145mir-3145miR-3145-3pmiR-3145-5p

Mechanism of action

Silencing of viral gene expression via direct RNA-RNA interaction leading to inhibition of viral polymerase (HBV pol region, influenza PB1 polymerase basic protein 1)

Biological functions

Inhibition of viral replicationRegulation of gene expressionResponse to cellular stressModulation of endoplasmic reticulum stressAntiviral activity

Disease associations

Viral infection (Hepatitis B virus, influenza A virus)Hepatocellular carcinoma (related via its host gene NHSL1)Other (potential in additional viral diseases inferred from mechanism)

Safety considerations

Potential off-target effectsChallenges in specific delivery of miRNA-based therapeutics to target tissuesImmune stimulation—general to RNA-based therapeutics

Interacting drugs

No clinically approved drugs specifically target miR-3145

2 more in the full profile.

Biomarkers

pri-miR-3145 levels serve as potential biomarkers for antiviral response or prognosis in HBV-infected hepatocellular carcinoma patients

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