microRNA 3148 (miR-3148)

MicroRNA 3148 (miR-3148) is a small non-coding RNA molecule that plays a regulatory role in gene expression at the posttranscriptional level. It modulates the fate and behavior of various cell types through direct interaction with specific mRNAs, decreasing their translation or promoting their degradation. miR-3148 has been shown to promote adipogenic differentiation and suppress osteogenic differentiation of human bone marrow stromal (mesenchymal) stem cells, in part by targeting and suppressing SMAD2—a critical mediator of the TGF-β pathway[1]. Overexpression of miR-3148 leads to increased cell proliferation, migration, invasion, and resistance to some chemotherapeutics in vitro, and contributes to malignant transformation and sarcoma-like tumor formation in vivo[1]. In glioma, miR-3148 is expressed at lower levels relative to healthy tissue; forced overexpression of miR-3148 in glioma cells suppresses cell proliferation, migration, and tumor growth by targeting DCUN1D1 and inhibiting the NF-κB signaling pathway, suggesting a tumor-suppressor function in that context[2]. In autoimmune disease, miR-3148 modulates allelic expression of Toll-like receptor 7, which may be relevant to systemic lupus erythematosus[3]. Currently, there are no direct therapeutic agents or small molecules in clinical use that specifically target miR-3148. miR-3148 is used as a biomarker for prognosis in certain cancers and curbing its expression or function has been explored for therapeutic benefit in preclinical models.

Other names

hsa-mir-3148mir-3148hsa-miR-3148MIR3148