MicroRNA 3162 (miR-3162)

MicroRNA 3162 (miR-3162) is a small, non-coding RNA belonging to the microRNA (miRNA) family, which plays a regulatory role in gene expression by binding to target messenger RNAs, leading to translational inhibition or mRNA degradation. miR-3162 is specifically implicated as a modulator of airway inflammation and hyperresponsiveness by directly targeting the 3′-UTR of β-catenin mRNA, leading to its downregulation; miR-3162-3p antagomir administration can alleviate asthma symptoms in experimental models. Like other miRNAs, it likely has broader, yet not fully mapped, roles in multiple biological pathways and diseases, although no approved drugs directly target miR-3162 at this time. Note: - MicroRNAs are not considered classical therapeutic targets (such as receptors or enzymes), but rather gene expression regulators and possible disease biomarkers, with antagomirs/mimics as experimental therapeutic agents. - The best-characterized role for miR-3162 is in asthma via β-catenin regulation. - The molecule is not misspelled or otherwise incorrect, but data is limited to a few disease-context studies.

Other names

hsa-mir-3162mir-3162hsa-miR-3162MIR3162

Antagomirs inhibit miR-3162-3p, leading to de-repression of target mRNAs such as β-catenin. Mimics increase miR-3162-3p, suppressing β-catenin mRNA and protein expression.