MicroRNA 3163 (miR-3163)

MicroRNA 3163 (miR-3163) is a small, non-coding RNA molecule that regulates gene expression post-transcriptionally by binding to target mRNAs, leading to their degradation or inhibition of translation. It has been identified as a tumor suppressor in several cancers, notably breast cancer, where its expression is significantly downregulated in tumor tissues compared to normal tissues. miR-3163 modulates metabolic pathways, cell cycle, and stress responses by targeting genes involved in glutamine metabolism, as well as signaling pathways such as MAPK, Wnt, and Hedgehog. In hepatocellular carcinoma, miR-3163 enhances tumor cell sensitivity to targeted therapies like sorafenib by directly inhibiting ADAM-17 and suppressing Notch signaling. Thus, miR-3163 is a promising therapeutic target and prognostic biomarker, with its modulation affecting cancer cell proliferation, apoptosis, and drug resistance, although its clinical utility remains under investigation due to complexities inherent to microRNA biology.

Other names

MIR3163hsa-mir-3163miR-3163

Enhancement of drug sensitivity (example: miR-3163 overexpression sensitizes HCC cells to sorafenib by inhibiting ADAM-17 and subsequent Notch signaling pathway)