MicroRNA 3173 (miR-3173)

MicroRNA 3173 (miR-3173, also known as hsa-mir-3173 or MIR3173) is a human microRNA gene composed of a short (20–24 nucleotide) non-coding RNA sequence[1]. MicroRNAs function as post-transcriptional regulators by binding to complementary regions in target mRNAs, most commonly resulting in inhibition of translation or destabilization of the mRNA. miR-3173 is encoded within the first intron of the DICER pre-mRNA and may play a role in regulating DICER expression, a protein crucial for miRNA biogenesis. Elevated expression levels of miR-3173 have been observed in several cancers, notably breast and ovarian cancer, where its increased presence has been correlated with poor progression-free survival and aggressive disease phenotypes. Both diagnostic and prognostic studies suggest miR-3173 shows strong sensitivity and specificity as a biomarker for these cancers. Its target genes are involved in a variety of biological pathways, including PI3K/AKT, Wnt/β-catenin, cell adhesion, EMT, DNA damage response, and oxidative stress response. No evidence supports its current use as a therapeutic target or direct drug interactions[2][1]. Key points: - MicroRNA 3173 is a non-coding RNA gene and not a classical drug target (like a receptor or enzyme)[1]. - It serves as a biomarker in breast and ovarian cancer for diagnosis and prognosis, not as a direct pharmacological target[2]. - Its functions in cancer appear to be mediated through regulation of gene expression affecting multiple oncogenic pathways and cellular processes[2].

Other names

hsa-mir-3173MIR3173mir-3173