MicroRNA 3180-3 (miR-3180-3)

MicroRNA 3180-3 (miR-3180-3) is a short (∼21–23 nucleotides), non-coding RNA belonging to the microRNA family, which functions as a post-transcriptional regulator of gene expression by binding imperfectly to target mRNAs, leading to their degradation or inhibition of translation. miR-3180-3 is upregulated in various types of cancer—including hepatocellular carcinoma and gastric cancer—and has been implicated as a potential prognostic biomarker, with higher expression levels correlating with poor patient outcomes. It regulates several cancer-critical genes such as CD81 and CDKN1A, influencing pathways related to cell cycle progression, proliferation, and metastasis. While it is not a direct target for approved drugs, its clinical significance is under investigation as a diagnostic and prognostic biomarker. The standard identifier for miR-3180-3 is hsa-miR-3180-3 (Ensembl: ENSG00000266291), and it is distinct from the incorrect code ENSG00000257563. The use of ENSG00000257563 for this miRNA is incorrect; miR-3180-3 is correctly annotated as ENSG00000266291 (Ensembl) and NCBI Gene ID 100422836. MicroRNAs such as miR-3180-3 are generally not therapeutic targets in the same protein-centric sense as most drug development, but may be targeted with antisense oligonucleotides or siRNA approaches. No interacting drugs or safety concerns specifically identified for this molecule in clinical use.

Other names

hsa-mir-3180-3MIR3180-3microRNA 3180-3miR-3180-3