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Target intelligence / Profile preview
microRNA 3184 (MIR3184)
- Target
- MIR3184
- Molecular classification
- Other (non-coding RNA), microRNA
01
Overview
microRNA 3184 (MIR3184) is a small, non-coding RNA molecule (microRNA; ~20-24 nucleotides) found in humans and involved in post-transcriptional regulation of gene expression, primarily by promoting mRNA degradation or inhibiting translation[3][5]. MIR3184 is enriched in cerebrospinal fluid exosomes from glioma patients and is linked to tumor progression by directly promoting glioma cell proliferation, migration, invasion, as well as inhibiting apoptosis. Additionally, glioma-derived exosomal MIR3184 can polarize macrophages toward an immunosuppressive M2-like phenotype, further enhancing tumor growth and immune evasion. As such, MIR3184 represents a potential biomarker for glioma and may indirectly influence tumor biology via effects on both tumor cells and the tumor immune microenvironment, but is not a classic therapeutic receptor or enzyme target[1][5].
- Other names
- hsa-mir-3184MIR3184-3pMIR3184-5p
02
Biological functions
Post-transcriptional gene regulationInhibition of apoptosisPromotion of cell proliferationPromotion of cell migration and invasionInduction of macrophage M2-like polarization
03
Disease associations
Cancer (specifically glioma/glioblastoma)Tumor progressionModulation of tumor immune microenvironment
04
Safety considerations
Potential off-target effects in therapeutic contexts affecting immune polarization and tumor progression
05
Biomarkers
Candidate biomarker for glioma diagnosis and monitoring via cerebrospinal fluid exosomes
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