MicroRNA 3184-3p (miR-3184-3p)

MicroRNA 3184-3p (miR-3184-3p) is a small, non-coding RNA molecule approximately 22 nucleotides in length that functions primarily in the post-transcriptional regulation of gene expression by binding to target messenger RNAs. It is notably enriched in cerebrospinal fluid exosomes of glioma patients and acts as an oncogenic regulator by promoting cell proliferation, migration, invasion, reducing apoptosis, and inducing epithelial-mesenchymal transition in cancer cells. In glioma, exosomal miR-3184-3p also contributes to tumor immune evasion by polarizing macrophages to a tumor-supportive M2-like phenotype. Additionally, miR-3184-3p levels are modulated in inflammatory diseases such as psoriasis, where it has been implicated in autophagy regulation and keratinocyte proliferation. It is not a protein-coding therapeutic target (like a receptor or enzyme) but is a regulatory RNA molecule with potential as a biomarker and indirect drug target[1][2][4][5][7][9].

Other names

hsa-miR-3184-3pmiRNA-3184-3p

Upregulation or downregulation by exogenous agents (e.g., PSORI-CM01 increases miR-3184-3p levels to modulate autophagy and proliferation) RNA interference or antagomir/inhibitor strategies (preclinical/experimental)