Target intelligence / Profile preview

MicroRNA 3185 (miR-3185)

Target
miR-3185
Molecular classification
MicroRNA, Non-coding RNA
01

Overview

MicroRNA 3185 (miR-3185, MIR3185) is a small, non-coding RNA molecule approximately 22 nucleotides in length, classified as a microRNA. It post-transcriptionally regulates gene expression by binding primarily to complementary sequences in the 3’ untranslated regions of target mRNAs, leading to translational repression or mRNA degradation. Although the specific target genes regulated by miR-3185 are not comprehensively mapped in current literature, miR-3185 has been identified as a potential biomarker in various cancers, including hepatocellular carcinoma and gastric cancer, where its presence in tissue and plasma correlates with diagnostic and/or prognostic outcomes. There are no approved drugs directly targeting miR-3185, nor is it considered a classical therapeutic target such as a receptor, enzyme, or transporter. Like other microRNAs, miR-3185 likely participates in broader cellular processes such as cell proliferation, apoptosis, and differentiation via modulation of gene expression, but disease-specific functions remain to be clearly delineated[2][3][4][5][6][7][9].

Other names
MIR3185hsa-mir-3185miR-3185hsa-miR-3185
02

Mechanism of action

Not applicable for drugs (no drugs are known to directly target miR-3185)

03

Biological functions

Gene regulationModulation of mRNA translation and stabilityPotentially involved in cell differentiation, proliferation, apoptosis (reflecting general microRNA functions[2][3][4][6][7])
04

Disease associations

Cancer (biomarker role in hepatocellular carcinoma and gastric cancer[5][9])Potential roles in other diseases via general miRNA mechanisms, though disease-specific evidence for miR-3185 is limited beyond biomarker associations
05

Safety considerations

None specific; as a microRNA biomarker, typical safety concerns relate to analytical validity (reproducibility, sensitivity, specificity), not drug-related toxicity
06

Biomarkers

Prognostic and diagnostic biomarker in various cancers, including: Hepatocellular carcinoma (HCC), where higher miR-3185 levels predict longer survival[5]Gastric cancer, where increased miR-3185 expression in tissue/plasma serves as a diagnostic biomarker[9]

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