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Target intelligence / Profile preview
MicroRNA 3187 (MIR3187)
- Target
- MIR3187
- Molecular classification
- microRNA (miRNA), non-coding RNA
01
Overview
MicroRNA 3187 (MIR3187) is a member of the human microRNA family, encoded by the MIR3187 gene located on chromosome 19. Like other microRNAs, MIR3187 is a short (20-24 nucleotides), non-coding RNA produced through a multi-step processing pathway: transcription by RNA polymerase II, cleavage by the Drosha enzyme to form a pre-miRNA, and final processing by Dicer to yield the mature miRNA. Mature MIR3187 is incorporated into the RNA-induced silencing complex (RISC), where it binds to complementary sequences in target mRNAs, typically resulting in repression of translation or mRNA degradation. Altered expression of MIR3187 is associated with certain congenital disorders and may also play a role in neoplastic and other disease physiology.
- Other names
- hsa-mir-3187mir-3187hsa-miR-3187
02
Biological functions
Post-transcriptional gene silencing (regulates mRNA stability and translation)Regulation of cell differentiation, proliferation, and apoptosis (implied from microRNA class function)
03
Disease associations
Cardiac valvular dysplasia, X-linkedCongenital disorder of glycosylation, type IicCancer (indirectly, as miRNAs regulate oncogenic and tumor suppressor pathways, and MIR3187-3p has expression changes in cancerous tissue)
04
Safety considerations
No specific safety concerns or therapeutic challenges are directly associated with targeting MIR3187, but microRNA-targeting therapies can risk off-target effects due to broad gene regulation
05
Biomarkers
MIR3187-3p expression changes have been identified as biomarkers in estrogen-regulated microRNA panels for HER2/ER signaling in breast cancerPotentially relevant in other disease contexts based on its regulatory impact as a miRNA
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