Target intelligence / Profile preview

MicroRNA 3191 (MIR3191)

Target
MIR3191
Molecular classification
Other (microRNA, non-coding RNA)
01

Overview

MicroRNA 3191 (MIR3191) is a small, non-coding RNA molecule belonging to the microRNA (miRNA) class. Like other miRNAs, MIR3191 regulates gene expression by binding to target messenger RNAs (mRNAs), which leads to either inhibition of translation or degradation of the target mRNA. MIR3191 is transcribed as part of a longer precursor RNA that is processed by the RNase III enzymes Drosha and Dicer to form the mature miRNA, which is subsequently loaded into the RNA-induced silencing complex (RISC). MIR3191 has been implicated in promoting migration and invasion of cancer cells by downregulating TGFBR2, and associations have been reported with diseases such as spinocerebellar ataxia. While microRNAs are increasingly studied as therapeutic targets and biomarkers, MIR3191 itself is not currently recognized as a direct therapeutic target by drugs or therapies[1][2][3].

Other names
hsa-mir-3191mir-3191
02

Biological functions

Post-transcriptional gene regulationmRNA destabilizationmRNA translational inhibition
03

Disease associations

CancerSpinocerebellar ataxia (specifically Spinocerebellar ataxia 6 and Autosomal dominant cerebellar ataxia)Other (general regulatory role in disease through gene expression modulation)
04

Biomarkers

Potential biomarker in cancer (general to microRNAs, specific evidence for MIR3191 as biomarker is lacking in provided results)[1][3]

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