MicroRNA-3200 (miR-3200)

MicroRNA-3200 is a member of the microRNA family, consisting of short (~22 nucleotides) non-coding RNAs that regulate gene expression post-transcriptionally by binding to complementary sequences in target mRNAs, leading to mRNA degradation or repression of translation. MicroRNA-3200 (including its arms, miR-3200-3p and miR-3200-5p) has been found to be downregulated in various cancers, such as glioma, where it acts as a tumor suppressor by targeting oncogenic pathways (notably, downregulating CAMK2A and affecting Ras/Raf/MEK/ERK signaling)[1]. It is also implicated as a biomarker in breast cancer, as changes in its serum expression correlate with disease burden and response to therapy[5]. In cardiovascular research, miR-3200-3p is linked to the regulation of ion channels and cardiac function[4]. Like other microRNAs, it is not itself a classical therapeutic receptor, enzyme, or transporter, but functions as a post-transcriptional regulator and biomarker with emerging potential as a therapeutic target via oligonucleotide-based strategies.

Other names

hsa-mir-3200mir-3200MIR3200miR-3200-3pmiR-3200-5p

Antisense oligonucleotides or miRNA mimics/inhibitors (general approach for miRNA targeting, but not specifically listed for miR-3200)