MicroRNA 320a (miR-320a)

MicroRNA 320a (miR-320a) is a short, non-coding RNA molecule that functions as a regulator of gene expression post-transcriptionally, predominantly by binding to the 3′-UTR of target mRNAs to inhibit their translation or promote degradation[7][3]. It is involved in controlling cell proliferation, apoptosis, migration, invasion, and cell cycle, and has been shown to act principally as a tumor suppressor in various human cancers, including gastric, renal, breast, testicular, and lung cancers, predominantly by downregulating oncogenes such as FOXM1, MTDH, and PD-L1[1][2][4]. It has utility as a biomarker for diagnosis and prognosis, most notably in breast cancer and non-small cell lung cancer, and its downregulation is frequently correlated with more aggressive clinical features and poorer survival[2][6][5]. No direct interacting drugs are currently established; its potential as a therapeutic target is under investigation, particularly in cancer, as modulation of miR-320a expression can significantly impact tumor cell biology[1][4][6].

Other names

hsa-miR-320aMIRN320MIRN320Ahsa-mir-320microRNA 320miR-320a-3p

Post-transcriptional gene silencing by binding to target mRNAs’ 3′-UTR and repressing translation or causing mRNA degradation