MicroRNA 320c-1 (miR-320c-1)

MicroRNA 320c-1 (miR-320c-1) is a small non-coding RNA molecule of the microRNA family that post-transcriptionally regulates gene expression by binding to target mRNAs, leading to mRNA degradation or translational inhibition[5]. miR-320c-1 is encoded in the human genome and functions as a regulatory molecule in diverse biological processes, including DNA damage response, cell proliferation, and apoptosis. It has been implicated in various diseases such as cancer (promoting or reducing chemoresistance by regulating genes like CHK1 and SMARCC1), osteoarthritis (serving as a plasma biomarker and affecting cytokine expression), and pulmonary disease (modulating SERPINA1 and inflammation). Due to these activities, miR-320c-1 is explored as a therapeutic target and biomarker for patient selection and monitoring in several clinical contexts[1][2][3][4][5].

Other names

hsa-mir-320c-1MIR320C-1MIRN320C1mir-320c-1MIR320C1

Modulates drug responsiveness by regulating target gene expression (e.g., suppresses DNA damage checkpoint kinase Chk1, regulates chromatin remodeling via SMARCC1, suppresses CREB5, regulates SERPINA1). miR-320c mimics or inhibitors can sensitize or desensitize tumor cells to chemotherapeutic agents by altering expression of key target genes