microRNA 320d-1 (MIR320D1)

microRNA 320d-1 (MIR320D1) is a small, non-coding RNA of the microRNA-320 family that regulates gene expression by binding to the 3′ untranslated regions (UTRs) of target mRNAs, leading to their silencing or degradation[4]. It is expressed at low levels in several human malignancies and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition of cancer cells[1][2][3]. Key experimentally validated targets of miR-320d-1 include TUSC3 (in colorectal cancer), FOXM1 (in gastric cardiac adenocarcinoma), and CDK6 (in lymphoma)[1][2][3]. Experimental restoration of MIR320D1 function suppresses oncogenic signaling pathways such as PI3K/Akt/mTOR and blocks EMT, contributing to its emerging role as a potential therapeutic target and biomarker for cancer prognosis[1][2][3][4]. If more structural, genomic, or pharmacological data become available in the future, these attributes may be updated. Currently, miR-320d-1 is not directly targeted by any approved drugs, but is actively researched as a therapeutic target in oncology.

Other names

miR-320d-1hsa-mir-320d-1microRNA-320d

Not applicable for currently marketed drugs. For experimental strategies: Restoration of miR-320d-1 expression leads to post-transcriptional suppression of target mRNAs (e.g., TUSC3, FOXM1, CDK6), resulting in anti-proliferative, anti-metastatic, and pro-apoptotic effects in cancer cells