MicroRNA-323b-5p target messenger RNAs (miR-323b-5p targets)

MicroRNA-323b-5p (miR-323b-5p) target messenger RNAs (mRNAs) represent a group of transcripts post-transcriptionally regulated by the miR-323b-5p microRNA through sequence-specific binding. This interaction typically occurs via the miRNA seed sequence (nucleotides 2-8) binding to complementary sites in the 3' untranslated regions (UTRs) of the target mRNAs, leading to translational repression or mRNA degradation (miRBase, 2024). miR-323b-5p is encoded within the DLK1-DIO3 imprinted cluster on chromosome 14, a region frequently associated with developmental disorders and various cancers. Key validated targets include TGFBR1 and SMAD2, which are central components of the TGF-beta signaling pathway, thereby positioning this target group as critical modulators of tissue fibrosis and the epithelial-mesenchymal transition (Ge et al., 2016, PubMed: 27153938). In clinical contexts, miR-323b-5p is often downregulated in conditions such as idiopathic pulmonary fibrosis (IPF), allowing for the pathological overexpression of its pro-fibrotic target proteins. Additionally, it has been implicated in regulating inflammatory mediators in asthma and acting as a tumor suppressor in several malignancies (TargetScan, 2024). Therapeutic strategies targeting these mRNAs involve the use of synthetic miRNA mimics to restore silencing or antagomirs to de-repress specific pathways, though challenges remain regarding delivery and off-target effects.

Other names

miR-323b-5p targetomehsa-miR-323b-5p target genesMicroRNA-323b-5p seed-matched mRNAsMessenger RNAs regulated by miR-323b-5p

Regulation of protein synthesis through RNA-induced silencing complex (RISC) mediated mRNA degradation or translational inhibition.